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, Jinhu Li Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University , Beijing 100871 , China Search for other works by this author on: Oxford Academic Dongfang Wang Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University , Beijing 100871 , China Corresponding author. E-mail: wangdf19@pku.edu.cn Search for other works by this author on: Oxford Academic Fei Tang Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University , Beijing 100871 , China Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871 , China Search for other works by this author on: Oxford Academic Xinnan Ling Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University , Beijing 100871 , China Search for other works by this author on: Oxford Academic Wenjie Zhang Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University , Beijing 100871 , China Search for other works by this author on: Oxford Academic Zemin Zhang Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University , Beijing 100871 , China Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871 , China Corresponding author. E-mail: zemin@pku.edu.cn Search for other works by this author on: Oxford Academic
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National Science Review, nwae231, https://doi.org/10.1093/nsr/nwae231
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11 July 2024
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Jinhu Li, Dongfang Wang, Fei Tang, Xinnan Ling, Wenjie Zhang, Zemin Zhang, Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancers, National Science Review, 2024;, nwae231, https://doi.org/10.1093/nsr/nwae231
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Abstract
Therapeutics targeting tumor endothelial cells (TECs) have been explored for decades, with only suboptimal efficacy achieved, partly due to an insufficient understanding of the TEC heterogeneity across cancer patients. We integrated single-cell RNA-seq data of 575 cancer patients from 19 solid tumor types, comprehensively charting the TEC phenotypic diversities. Our analyses uncovered underappreciated compositional and functional heterogeneity in TECs from a pan-cancer perspective. Two subsets, CXCR4+ tip cells and SELE+ veins, represented the prominent angiogenic and proinflammatory phenotypes of TECs, respectively. They exhibited distinct spatial organization patterns, and compared to adjacent non-tumor tissues, tumor tissue showed an increased prevalence of CXCR4+ tip cells, yet with SELE+ veins depleted. Such functional and spatial characteristics underlie their differential associations with the response of anti-angiogenic therapies and immunotherapies. Our integrative resources and findings open new avenues to understand and clinically intervene in the tumor vasculature.
tumor endothelial cell, pan-cancer, single-cell RNA-seq, immunotherapy
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Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
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Equally contributed to this work.
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© The Author(s) 2024. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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